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Protein Chemical Synthesis by Ligation of Peptide Hydrazides

2011; Wiley; Volume: 50; Issue: 33 Linguagem: Inglês

10.1002/anie.201100996

1521-3773

Ge‐Min Fang, Yi‐Ming Li, Fei Shen, Yichao Huang, Jiabin Li, Yun Lin, Hong‐Kui Cui, Lei Liu,

Peptidase Inhibition and Analysis

pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long-sought reagent equivalent to a "thioester synthon", one that is stable to the conditions of native chemical ligation. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.