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Ability of Peripapillary Atrophy Parameters to Differentiate Normal-tension Glaucoma From Glaucomalike Disk

2001; Lippincott Williams & Wilkins; Volume: 10; Issue: 2 Linguagem: Inglês

10.1097/00061198-200104000-00005

1536-481X

Ki Ho Park, S. Park, Yong‐Jae Lee, Jaeryung Kim, Joseph Caprioli,

Corneal surgery and disorders

Purpose To investigate the ability of peripapillary atrophy (PPA) parameters to differentiate normal-tension glaucoma (NTG) from glaucomalike disk (GLD). Methods Thirty-three eyes of 33 patients with GLD that had no evidence of visual field defect and retinal nerve fiber layer defect and 33 eyes of 33 patients with NTG, matched with age and intraocular pressure, were enrolled. The participants were selected from the database of patients referred from a routine health checkup because of high cup-to-disk ratio (>0.5). Topographic measurements for the optic disk were performed using the Heidelberg Retina Tomograph (HRT). The extent of PPA (zone β) was measured with Atrophy Zone Analysis software of HRT. Receiver operating characteristic (ROC) curves (GraphROC version 2.0) were used to compare the new formula including PPA parameters with that of the HRT discriminant analysis formula in differentiating NTG from GLD. Results The area of zone β, atrophy-to-disk area ratio, and angular and radial extent of zone β were significantly larger in NTG (P < 0.01). Multiple logistic regression analysis showed that rim area and corrected radial extent of zone β are variables that show significant difference between NTG and GLD (P < 0.05). The area under the ROC curve for the new formula including rim area and corrected radial extent of zone β (0.8655) was significantly larger than that for the HRT discriminant analysis formula (0.7351) (P = 0.0128). Conclusion The PPA measurement obtained by HRT can be a useful additional tool to differentiate NTG from GLD after the first screening by disk photograph in a routine health checkup.