Effect of candicidin on cholesterol and bile acid metabolism in the rat
1981; Wiley; Volume: 16; Issue: 6 Linguagem: Inglês
10.1007/bf02535009
ISSN1558-9307
AutoresAnil Singhal, Erwin H. Mosbach, Carl P. Schaffner,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoAbstract Sterol metabolism studies were carried out in rats maintained on a diet containing a polyene antibiotic, candicidin, (30 mg/kg/day) for 2‐1/2 months. Compared to the controls, the candicidintreated animals had a smaller food intake and weight gain during this period. There was no difference between the 2 groups in serum cholesterol levels, biliary cholesterol or bile acid concentrations. However, in the experimental group, liver cholesterol content decreased by 27% and hepatic HMG‐CoA reductase increased by 36%. Candicidin administration produced an 84% increase in neutral sterol output without change in bile acid output. Cholesterol absorption was reduced 80% by candicidin feeding. The weight of ventral prostate was reduced 33% by candicidin administration. Prostatic HMG‐CoA reductase levels were 3 times higher than those of the liver, but enzyme activity was unchanged by candicidin treatment.
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