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Legionnaires’ Disease Outbreak in Murcia, Spain

2003; Centers for Disease Control and Prevention; Volume: 9; Issue: 8 Linguagem: Inglês

10.3201/eid0908.030337

1080-6059

Ana Garcı́a-Fulgueı́ras, Carmen Navarro, Daniel Fenoll, J.M. Sánchez García, Paulino González Diego, María Teresa Jiménez-Buñuales, Miguel Rodríguez‐Barranco, Rosa López, Francisco Granados Pacheco, Joaquín Ruiz, Manuel Segovia, Beatriz Baladrón, C. Pelaz,

Pleural and Pulmonary Diseases

An explosive outbreak of Legionnaires' disease occurred in Murcia, Spain, in July 2001. More than 800 suspected cases were reported; 449 these cases were confirmed, which made this the world's largest outbreak of the disease reported to date. Dates of onset for confirmed cases ranged from June 26 to July 19, with a case-fatality rate of 1%. The epidemic curve and geographic pattern from the 600 competed epidemiologic questionnaires indicated an outdoor point-source exposure in the northern part of the city. A case-control study matching 85 patients living outside the city of Murcia with two controls each was undertaken to identify to outbreak source; the epidemiologic investigation implicated the cooling towers at a city hospital. An environmental isolate from these towers with an identical molecular pattern as the clinical isolates was subsequently identified and supported that epidemiologic conclusion.