Antibody-targeted HPMA copolymer-bound anthracycline antibiotics
2003; Thomson Reuters; Volume: 28; Issue: 12 Linguagem: Inglês
10.1358/dof.2003.028.12.857390
ISSN2013-0368
Autores Tópico(s)Cancer Research and Treatments
ResumoConjugates based on N-(2-hydroxypropyl)methacryl-amide (HPMA) represent a new generation of polymeric anticancer drugs with improved therapeutic potential and considerably decreased nonspecific side effects. Antibody-targeted derivatives show specific active targeting and nonspecific passive accumulation in solid tumors due to the enhanced permeability and retention (EPR) effect, decreased immunogenicity of conjugated proteins, long-term circulation in the bloodstream, partial activity towards multidrug-resistant (MDR) cells, and immunoprotective and immunomobilizing activities in vivo. Conjugates of HPMA and doxorubicin containing intravenous human immunoglobulin (IVIg) were used as a palliative treatment in patients with advanced cancer.
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