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A rise in the percentage of large unstained cells in the peripheral blood determined by the Hemalog D90 automated differential counter is a feature of impending myeloid engraftment following bone marrow transplantation

1986; Wiley; Volume: 8; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2257.1986.tb00069.x

1365-2257

Philippe Martin, Charles C. Anderson, H.M. Jones, A.P. Lai, David C. Linch, A. H. Goldstone,

Acute Myeloid Leukemia Research

The early phase of bone marrow regeneration has been monitored by automated differential counts on the peripheral blood using a Hemalog D90, following 107 transplant procedures. An elevated percentage of large unstained cells (LUCs) was detected in over 98% of cases and in 72% of cases the rise in percentage LUCs preceded the rise of the total leucocyte count into the detectable range on a Coulter counter (greater than 0.3 X 10(9)/1) by an average of 4 days. These LUCs are shown to be CD8 + T lymphocytes. The ability to detect the earliest signs of regeneration is particularly useful when regeneration is delayed and repeat marrow infusion is considered.