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Development of a diagnostic system for osteoarthritis using a photoacoustic measurement method

2006; Wiley; Volume: 38; Issue: 3 Linguagem: Inglês

10.1002/lsm.20285

1096-9101

Miya Ishihara, Masato Sato, Nagatoshi Kaneshiro, Genya Mitani, Shunichi Sato, Joji Mochida, Makoto Kikuchi,

Photoacoustic and Ultrasonic Imaging

Lasers in Surgery and MedicineVolume 38, Issue 3 p. 249-255 Basic Research Development of a diagnostic system for osteoarthritis using a photoacoustic measurement method Miya Ishihara PhD, Corresponding Author Miya Ishihara PhD kobako@ndmc.ac.jp Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanDepartment of Medical Engineering, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 359-8513, Japan.Search for more papers by this authorMasato Sato MD, PhD, Masato Sato MD, PhD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorNagatoshi Kaneshiro MD, Nagatoshi Kaneshiro MD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorGenya Mitani MD, Genya Mitani MD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorShunichi Sato PhD, Shunichi Sato PhD National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanSearch for more papers by this authorJoji Mochida MD, PhD, Joji Mochida MD, PhD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorMakoto Kikuchi PhD, Makoto Kikuchi PhD Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanSearch for more papers by this author Miya Ishihara PhD, Corresponding Author Miya Ishihara PhD kobako@ndmc.ac.jp Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanDepartment of Medical Engineering, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama 359-8513, Japan.Search for more papers by this authorMasato Sato MD, PhD, Masato Sato MD, PhD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorNagatoshi Kaneshiro MD, Nagatoshi Kaneshiro MD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorGenya Mitani MD, Genya Mitani MD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorShunichi Sato PhD, Shunichi Sato PhD National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanSearch for more papers by this authorJoji Mochida MD, PhD, Joji Mochida MD, PhD Department of Orthopaedic Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, JapanSearch for more papers by this authorMakoto Kikuchi PhD, Makoto Kikuchi PhD Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanSearch for more papers by this author First published: 16 February 2006 https://doi.org/10.1002/lsm.20285Citations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Background and Objectives We demonstrated that photoacoustic measurement enables viscoelastic characterization of biological tissue. The purpose of this study was to develop a practical photoacoustic measurement system for diagnosis of osteoarthritis (OA) by viscoelastic characterization of articular cartilage. Study Design/Materials and Methods The portable system consists of a commercially available 3rd harmonic Q-switched Nd:YAG laser as a light source and a transducer, which is arranged coaxially with an optical fiber. Cell proliferation tests were performed to study the effect of laser irradiation on chondrocytes. Photoacoustic measurements were performed using enzymatically treated cartilage as a model of OA. Results There was no significant damage of chondrocytes caused by laser irradiation (100 µJ/mm2, 5 Hz, 30 shots). The change in relaxation times measured by the photoacoustic measurement had a positive correlation with time of enzymatic treatment, that is, the degree of cartilage degeneration. Conclusions We have developed a noninvasive photoacoustic measurement system designed for arthroscopic use and have demonstrated the applicability of this system to the diagnosis of OA-like cartilage degeneration. Lasers Surg. Med. 38:249–255, 2006. © 2006 Wiley-Liss, Inc. Citing Literature Volume38, Issue3March 2006Pages 249-255 RelatedInformation