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The effect of DDT on the level of Di- and triphosphopyridine nucleotides in Triatoma infestans

1963; Elsevier BV; Volume: 13; Issue: 2 Linguagem: Inglês

10.1016/0014-4894(63)90071-7

1090-2449

Manuel R. Agosín, María Luisa Dinamarca,

Diet, Metabolism, and Disease

1. The levels of oxidized and reduced pyridine nucleotides have been measured in normal and DDT- and DDE-treated nymphs and adult males of T. infestans. 2. The total content of DPN (DPN plus DPNH) is higher than TPN (TPN plus TPNH) in both nymphs and males. In nymphs, DPN is mainly present in the oxidized form and TPN in the reduced form, while in males TPN is mainly found in the reduced form and DPN in the oxidized form. 3. DDT significantly increases the total TPN content in nymphs, but does not affect the ratio TPN/TPNH, while in males neither the total TPN level nor the ratio TPN/TPNH, are changed. 4. DDT significantly increases the total content of DPN in males after 24 hours of intoxication. DDE is without any effect on the DPN or TPN levels in nymphs and males, but the ratios DPN/DPNH, are significantly increased in males.