Produção Nacional
Revisado por pares
Prognostic and predictive value of the thymidylate synthase expression in patients with non-metastatic colorectal cancer
2005; Elsevier BV; Volume: 31; Issue: 8 Linguagem: Inglês
10.1016/j.ejso.2005.03.014
ISSN1532-2157
AutoresSamuel Aguiar, Ademar Lopes, Fernando Augusto Soares, Bernard Rossi, Florbela Ferreira, Wilson Toshihiko Nakagawa, André Lopes Carvalho, Waldec Jorge David Filho,
Tópico(s)Colorectal Cancer Screening and Detection
ResumoTo assess the value of thymidylate synthase (TS) expression as a predictive factor in the efficacy of adjuvant chemotherapy in colorectal cancer, as well as its independent prognostic value for survival.We studied 114 high risk colorectal carcinoma patients (high risk stage II and stage III), distributed in two treatment groups: surgery alone (61 patients) or surgery followed by 5-FU-based chemotherapy (53 patients). TS protein expression in the tumour tissue was assessed by immunohistochemistry.In the surgery alone subgroup, overall survival (OS) at 5 years were 77.5% for the patients with low TS expression, against 57.7% for the patients with high TS expression (p=0.006). Among patients with low TS, there was no difference in OS as a result of whether adjuvant chemotherapy was carried out or not (65.8 vs 77.5%, p=0.29). Among the patients with high TS, there was a significant gain in OS in favor of chemotherapy (87.8 vs 57.7%, p=0.04). Analyzing the complete sample, TS expression was not shown as an independent prognostic factor for survival in the multivariate analysis.The immunohistochemical TS expression may be used for selecting patients for better adjuvant chemotherapy protocols. In this sample, TS expression was not an independent prognostic factor for survival.
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