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Enzymic interconversion of fatty alcohols and fatty acids

1970; Elsevier BV; Volume: 41; Issue: 6 Linguagem: Inglês

10.1016/0006-291x(70)90540-1

1090-2104

Fred Snyder, Boyd Malone,

Cancer, Lipids, and Metabolism

The enzymic reduction of l-14C-palmitic acid to hexadecanol and the enzymic oxidation of l-14C-hexadecanol to palmitic acid have been demonstrated in unwashed microsomes from mouse preputial gland tumors. NAD is required for oxidation and NADPH is required for reduction. ATP, CoA, and Mg++ are also required for the reduction of fatty acids (presumably for activation) but they are not necessary for the oxidation of fatty alcohols.