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Impact of ubiquinone (coenzyme Q 10 ) treatment on glycaemic control, insulin requirement and well‐being in patients with Type 1 diabetes mellitus

1999; Wiley; Volume: 16; Issue: 4 Linguagem: Inglês

10.1046/j.1464-5491.1999.00064.x

1464-5491

Jan Erik Henriksen, Claus Andersen, Ole Hother‐Nielsen, Allan Vaag, Svend Mortensen, Henning Beck-Nielsen,

Biochemical effects in animals

Summary Aim To investigate the effect of ubiquinone (coenzyme Q 10 ) on glycaemic control and insulin requirement in patients with Type 1 diabetes mellitus (DM). Methods We investigated 34 patients with Type 1 DM in a randomized, double‐blind, placebo‐controlled study. Patients received either 100 mg Q 10 or placebo daily for 3 months. The insulin doses were adjusted according to patients’ home measurements of blood glucose concentrations and reported experience of hypoglycaemia. Results At randomization no differences existed between the Q 10 and the placebo groups in age, body mass index (BMI), HbA 1c , daily insulin dose or mean daily blood glucose concentration. Serum Q 10 concentration increased in the Q 10 group (mean ± sd : 0.9 ± 0.2 vs. 2.0 ± 1.0 μg/ml, P < 0.005), with no change in the placebo group (0.9 ± 0.3 vs. 0.9 ± 0.3 μg/ml, not significant (NS)). Following intervention no differences existed between the Q 10 and the placebo groups regarding HbA 1c (7.86 ± 0.88 vs. 7.84 ± 0.84%), mean daily blood glucose concentrations (8.06 ± 1.86 vs. 8.53 ± 1.88 m m ), mean insulin dose (52.1 ± 13.2 vs. 52.6 ± 21.4 U), hypoglycaemic episodes (2.0 ± 1.8 vs. 2.5 ± 2.1 episodes/week), or cholesterol concentrations (4.81 ± 0.91 vs. 4.78 ± 1.07 m m ). Furthermore, no differences existed in the well‐being of the patients reported from a visual analogue scale (physical: 0.67 ± 0.21 vs. 0.71 ± 0.18, psychological: 0.70 ± 0.25 vs. 0.73 ± 0.24). Conclusion Q 10 treatment does not improve glycaemic control, nor does it reduce insulin requirement, and it can therefore be taken by patients with Type 1 DM without any obvious risk of hypoglycaemia. No major beneficial or unfavourable effects on the investigated parameters could be demonstrated and no major changes in the sense of well‐being occurred in the patients. Diabet. Med. 16, 312–318 (1999)