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Adverse Interaction Between Beta-adrenergic Blocking Drugs and Verapamil-Report of Three Cases

1982; Wiley; Volume: 12; Issue: 4 Linguagem: Inglês

10.1111/j.1445-5994.1982.tb03813.x

0004-8291

Victor S. Wayne, Richard W. Harper, E. Laufer, Jacob Federman, S. T. Anderson, A. Pitt,

Epilepsy research and treatment

Australian and New Zealand Journal of MedicineVolume 12, Issue 4 p. 285-289 Adverse Interaction Between Beta-adrenergic Blocking Drugs and Verapamil–Report of Three Cases V. S. Wayne, V. S. Wayne Cardiology Service, Alfred Hospital, Melbourne, Victoria *Cardiology Registrar.Search for more papers by this authorR. W. Harper, R. W. Harper Cardiology Service, Alfred Hospital, Melbourne, Victoria †Cardiologist.Search for more papers by this authorE. Laufer, E. Laufer Cardiology Service, Alfred Hospital, Melbourne, Victoria ‡Visiting Assistant Physician.Search for more papers by this authorJ. Federman, J. Federman Cardiology Service, Alfred Hospital, Melbourne, Victoria †Cardiologist.Search for more papers by this authorS. T. Anderson, S. T. Anderson Cardiology Service, Alfred Hospital, Melbourne, Victoria **Deputy Director.Search for more papers by this authorA. Pitt, Corresponding Author A. Pitt Cardiology Service, Alfred Hospital, Melbourne, Victoria ††Director, Associate Professor of Medicine.Cardiology Service, Alfred Hospital, Commercial Road, rahran, Victoria 3181Search for more papers by this author V. S. Wayne, V. S. Wayne Cardiology Service, Alfred Hospital, Melbourne, Victoria *Cardiology Registrar.Search for more papers by this authorR. W. Harper, R. W. Harper Cardiology Service, Alfred Hospital, Melbourne, Victoria †Cardiologist.Search for more papers by this authorE. Laufer, E. Laufer Cardiology Service, Alfred Hospital, Melbourne, Victoria ‡Visiting Assistant Physician.Search for more papers by this authorJ. Federman, J. Federman Cardiology Service, Alfred Hospital, Melbourne, Victoria †Cardiologist.Search for more papers by this authorS. T. Anderson, S. T. Anderson Cardiology Service, Alfred Hospital, Melbourne, Victoria **Deputy Director.Search for more papers by this authorA. Pitt, Corresponding Author A. Pitt Cardiology Service, Alfred Hospital, Melbourne, Victoria ††Director, Associate Professor of Medicine.Cardiology Service, Alfred Hospital, Commercial Road, rahran, Victoria 3181Search for more papers by this author First published: August 1982 https://doi.org/10.1111/j.1445-5994.1982.tb03813.xCitations: 44 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Abstract: Adverse interaction between beta-adrenergic blocking drugs and verapamil–report of three cases. V. S. Wayne, R. W. Harper, E. Laufer, J. Federman, S. T. Anderson and A. Pitt, Aust. N.Z. J. Med., 1982, 12, pp. 285–289. Three patients with ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs. This clinical picture resolved completely with cessation of the combined therapy. Baseline left ventricular function, assessed by cardiac catheterisation or nuclear angiography, was normal in two patients and only mildly reduced in the other. Simultaneous administration of beta-adrenergic blocking drugs and verapamil may result in profound adverse interactions and should only be administered with great caution. References 1 Hutter AM, DeSanctis RW. The evaluation and management of patients with angina pectoris. In: RA Johnson et al. eds. The Practice of Cardiology. Boston : Little Brown and Co. 1980: 283–309. 2 Krikler D. Verapamil in cardiology. Eur J Cardiol 1974; 2(1): 3–10. 3 Nayler WG, Krikler D. Verapamil and the myocardium. 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Circulation 1980; 62, Supp 1111: 87. 15 Hugenholtz PG, Michels HR, Serruys PW, Brower RW. Nifedipine in the treatment of unstable angina, coronarv spasm and myocardial ischaemia. Arn J Cardiol 1981; 47: 163–73. Citing Literature Volume12, Issue4August 1982Pages 285-289 ReferencesRelatedInformation