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Homologs of dopa, .alpha.-methyldopa, and dopamine as potential cardiovascular drugs

1975; American Chemical Society; Volume: 18; Issue: 4 Linguagem: Inglês

10.1021/jm00238a024

1520-4804

Mary E. Winn, Rune Rasmussen, Frederick N. Minard, Jaroslav Kynčl, Nicholas P. Plotnikoff,

Neurotransmitter Receptor Influence on Behavior

Starting from 3,4-dimethoxyphenacyl bromide, 2-amino-4-(3,4-dihydroxyphenyl)butyric acid (homodopa) was synthesized in six steps. 5-Hydroxyhomodopa was similarly prepared. alpha-Methylhomodopa was synthesized in four steps from zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone]. alpha-Methylhomodopa showed no antihypertensive activity in the genetic hypertensive rat. Homodopa did not potentiate the behavioral effect of Dopa or inhibit Dopa decarboxylase. Homodopamine, unlike dopamine, did not increase renal blood flow in the dog.