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Inhibitory effects of chlorophyllin on micronucleus formation induced by ethyl carbamate and its proximate and ultimate carcinogenic forms in mouse peripheral reticulocytes

1999; Wiley; Volume: 34; Issue: 1 Linguagem: Inglês

10.1002/(sici)1098-2280(1999)34

1098-2280

Seong‐Gon Kim, Young‐Joon Surh, James A. Miller,

Genomics, phytochemicals, and oxidative stress

Environmental and Molecular MutagenesisVolume 34, Issue 1 p. 57-60 Brief Communications Inhibitory effects of chlorophyllin on micronucleus formation induced by ethyl carbamate and its proximate and ultimate carcinogenic forms in mouse peripheral reticulocytes Seong Gon Kim, Seong Gon Kim McArdle Laboratory for Cancer Research, School of Medicine, University of Wisconsin, Madison, WisconsinSearch for more papers by this authorYoung-Joon Surh, Corresponding Author Young-Joon Surh [email protected] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, KoreaCollege of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-gu, Seoul 151-742, South KoreaSearch for more papers by this authorJames A. Miller, James A. Miller McArdle Laboratory for Cancer Research, School of Medicine, University of Wisconsin, Madison, WisconsinSearch for more papers by this author Seong Gon Kim, Seong Gon Kim McArdle Laboratory for Cancer Research, School of Medicine, University of Wisconsin, Madison, WisconsinSearch for more papers by this authorYoung-Joon Surh, Corresponding Author Young-Joon Surh [email protected] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, KoreaCollege of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-gu, Seoul 151-742, South KoreaSearch for more papers by this authorJames A. Miller, James A. Miller McArdle Laboratory for Cancer Research, School of Medicine, University of Wisconsin, Madison, WisconsinSearch for more papers by this author First published: 25 August 1999 https://doi.org/10.1002/(SICI)1098-2280(1999)34:1 3.0.CO;2-2Citations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Abraham SK, Sharma L, Kesavan PC. 1994. Role of chlorophyllin as an in vivo anticlastogen: protection against gamma-radiation and chemical clastogens. Mutat Res 322: 209–212. Medline Amara-Mokrane YA, Lehucher-Michel MP, Balansard G, Dumenil G, Botta A. 1996. Protective effects of a-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes. Mutagenesis 11: 161–167. Medline Arimoto S, Fukuoka S, Itome C, Nakano H, Rai H, Hayatsu H. 1993. Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenicity. Mutat Res 287: 293–305. Medline Block G, Patterson B, Subar A. 1992. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18: 1–29. Medline Breinholt V, Schimerlick M, Dashwood R, Bailey G. 1995. Mechanisms of chlorophyllin anticarcinogenesis against aflatoxcin B1: Complex formation with the carcinogen. Chem Res Toxicol 8: 506–514. Medline Bronzetti G, Galli A, Della Croce DM. 1990. Anti-mutagenic effects of chlorophyllin. In: Y Kuroda, DM Shankel, MD Waters, editors. Antimutagenesis and anticarcinogenesis mechanisms, vol. II. New York: Plenum Press. p 463–468. Camiano A, Balansky RM, Bennicelli C, Izzotti A, DíAgostini FD, De Flora S. 1994. Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke. Mutat Res 317: 89–109. Medline Dashwood R, Guo D. 1993. Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagens-inhibitor complexes. Environ Mol Mutagen 22: 164–171. Medline Dashwood RH, Breinholt V, Bailey GS. 1991. Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay. Carcinogenesis 12: 939–942. Medline Espinosa-Aguirre JJ, Reyes RE, Rubio J, Ostrosky-Wegman P, Martinez G. 1993. Mutagenic activity of urban air samples and its modulation by chili extracts. Mutat Res 303: 55–61. Medline Guo D, Dashwood R. 1994. Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in liver and colon. Carcinogenesis 15: 173–766. Hayashi M, Morita T, Kodama Y, Sofuni T, Ishidate M Jr. 1990. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat Res 245: 245–249. Medline Hayatsu H, Negishi T, Arimoto S, Hayatsu T. 1993. Porphyrins as potential inhibitors against exposure to carcinogens and mutagens. Mutat Res 290: 79–85. Medline Imai K, Aimoto T, Sato M, Watanabe K, Kimura R, Murata T. 1986. Effects of sodium metalochlorophyllin on the activity and components of the microsomal drug-metabolizing enzyme system in rat liver. Chem Pharm Bull 34: 4287–4293. Medline Kishi M, Horiguchi Y, Watanabe S, Hayashi M. 1992. Validation of the mouse peripheral blood micronucleus assay using acridine orange supravital staining with urethane. Mutat Res 278: 205–208. Medline Lai C-N, Butler MA, Matney TS. 1980. Antimutagenic activities of common vegetables and their chlorophyll content. Mutat Res 77: 245–250. Morales-Ramirez P, Garcia-Rodriguez MC. 1994. In vivo effect of chlorophyllin on (γ-ray-induced sister chromatid exchange in murine bone marrow cells. Mutat Res 320: 329–334. Medline Negishi T, Nakano H, Kitamura A, Itome C, Shiotani T, Hayatsu H. 1994. Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila. Cancer Lett 83: 157–164. Medline Nelson RL. 1992. Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res 12: 737–740. Medline Olvera O, Zimmering S, Arceo C, Cruces M. 1993. The protective effects of chlorophyllin in treatment of chromium (VI) oxide in somatic cells of Drosophila. Mutat Res 301: 201–204. Medline Ong T-M, Whong W-Z, Stewart J, Brockman HE. 1986. Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutat Res 173: 111–115. Medline Park K-K, Surh Y-J. 1996. Chemopreventive activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. Cancer Lett 102: 143–149. Medline Park K-K, Surh Y-J, Stewart BC, Miller JA. 1990. Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate. Biochem Biophys Res Commun 169: 1094–1098. Medline Park K-K, Surh Y-J, Miller JA. 1995. Chemoprotective properties of chlorophyllin against vinyl carbamate, p-nitrophenyl vinyl ether and their electrophilic epoxides. Cancer Lett 94: 33–40. Medline Renner HW. 1990. In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations. Mutat Res 244: 185–188. Medline Sarkar D, Sharma A, Talukder G. 1993. Differential protection of chlorophyllin against clastogenic effects of chromium and chlordane in mouse bone marrow in vivo. Mutat Res 301: 33–38. Medline Sato M, Imai K, Kimura R, Murata T. 1984. Effects of sodium-copper chlorophyllin on lipid peroxidation. VI. Effects of its administration on mitochondria and lipid peroxidation in rat liver. Chem Pharm Bull 32: 716–722. Medline Stavric B. 1994. Antimutagens and aniticarcinogens in foods. Food Chem Toxicol 32: 79–90. Medline Tachino N, Guo D, Dashwood WM, Yamane S, Larsen R, Dashwood R. 1994. Mechanism of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res 308: 191–203. Medline Whong W-Z, Stewart J, Brockman HE, Ong T-m. 1988. Comparative antimutagenicity of chlorophyllin and five other agents against aflatoxin B1-induced reversion in Salmonella typhimurium strain TA98. Teratogen Carcinogen Mutagen 8: 215–224. Wild D. 1991. Micronucleus induction in bone marrow by vinyl carbamate, a hypothetical metabolite of the carcinogen urethane (ethyl carbamate). Mutat Res 260: 309–310. Medline Yun C-H, Jeong HG, Jhoun JW, Guengerich FP. 1995. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. Carcinogenesis 16: 1437–1440. Medline Citing Literature Volume34, Issue11999Pages 57-60 ReferencesRelatedInformation