Produção Nacional
Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats
1999; Elsevier BV; Volume: 33; Issue: 1 Linguagem: Inglês
10.1016/s0306-3623(98)00267-5
ISSN1879-0011
AutoresCarlos Alberto Tagliati, Elza Kimura, Michael Simon Nothenberg, Sı́lvia R.J.C Santos, Seizi Oga,
Tópico(s)Pharmacological Effects and Toxicity Studies
ResumoComplexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on carrageenin-induced paw edema. Zinc-piroxicam is less irritating than piroxicam on the gastric mucosa.
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