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An overview of malaria transmission from the perspective of Amazon Anopheles vectors

2015; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 110; Issue: 1 Linguagem: Inglês

10.1590/0074-02760140266

1678-8060

Paulo FP Pimenta, Alessandra S Orfanó, Ana C. Bahia, Ana Paula Duarte, Claudia María Ríos-Velásquez, Fabrício Freire de Melo, Felipe Arley Costa Pessoa, Giselle A. Oliveira, Keillen Monick Martins-Campos, Luís Eduardo Martinez Villegas, Nilton Barnabé Rodrigues, Rafael Nacif-Pimenta, Rejane de Castro Simões, Wuelton Marcelo Monteiro, Rogério Amino, Yara Maria Traub-Csekö, José B. P. Lima, Maria G. V. Barbosa, Marcus Lacerda, Wanderli Pedro Tadei, Nágila F. C. Secundino,

Mosquito-borne diseases and control

In the Americas, areas with a high risk of malaria transmission are mainly located in the Amazon Forest, which extends across nine countries. One keystone step to understanding the Plasmodium life cycle in Anopheles species from the Amazon Region is to obtain experimentally infected mosquito vectors. Several attempts to colonise Ano- pheles species have been conducted, but with only short-lived success or no success at all. In this review, we review the literature on malaria transmission from the perspective of its Amazon vectors. Currently, it is possible to develop experimental Plasmodium vivax infection of the colonised and field-captured vectors in laboratories located close to Amazonian endemic areas. We are also reviewing studies related to the immune response to P. vivax infection of Anopheles aquasalis, a coastal mosquito species. Finally, we discuss the importance of the modulation of Plasmodium infection by the vector microbiota and also consider the anopheline genomes. The establishment of experimental mosquito infections with Plasmodium falciparum, Plasmodium yoelii and Plasmodium berghei parasites that could provide interesting models for studying malaria in the Amazonian scenario is important. Understanding the molecular mechanisms involved in the development of the parasites in New World vectors is crucial in order to better determine the interaction process and vectorial competence.