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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study

2005; Instituto de Tecnologia do Paraná (Tecpar); Volume: 48; Issue: spe2 Linguagem: Inglês

10.1590/s1516-89132005000700013

ISSN

1678-4324

Autores

Álvaro Dutra de Carvalho Júnior, Fabiana Moreira ABRANTES, Maria Ângela de Barros Correia Menezes, Alexandre Soares Leal, Valbert Nascimento Cardoso, Mônica Cristina Oliveira,

Tópico(s)

Radiopharmaceutical Chemistry and Applications

Resumo

This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.

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