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A new triterpenoid from roots of Laportea crenulata and its antifungal activity

2007; Taylor & Francis; Volume: 21; Issue: 11 Linguagem: Inglês

10.1080/14786410701371470

1478-6427

Alam Khan, Mohammad Rashedul Haque, M. Mukhlesur Rahman, Ashik Mosaddik, Motiur Rahman, Nasim Sultana,

Phytochemistry and Bioactive Compounds

Abstract A new triterpenoid 2α,3β,21β,23,28-penta hydroxyl 12-oleanene and two known compounds were isolated from the roots of Laportea crenulata Gaud. The structures of all compounds were elucidated on the basis of various spectroscopic data. The two known compounds β-sitosterol and β-sitosterol 3-β-D-glucopyranoside are also the first report of isolation from this plant. The antifungal activity of new triterpenoid was studied against Aspergillus flavus, Aspergillus niger, Candida albicans, and Rhizopus aurizae, and compared with the activity of nystatin (30 µg disc−1). This compound has shown moderate activity against tested fungi. Keywords: Laportea crenulata2α,3β,21β,23,28-Penta hydroxyl 12-oleaneneAntifungal activity Acknowledgements The authors wish to thank to Professor A.T.M. Naderuzzaman, Department of Botany, University of Rajshahi, Bangladesh for identification of the plant. We express our thanks to the Centre for Phytochemistry and Pharmacology, Southern Cross University, Australia for running NMR and liquid chromatography/electrospray-mass spectra. Thanks are also provided to the Chemistry Department of Wollongong University, NSW, Australia for Providing HR-Mass data.