Portal de Periódicos da CAPES

Brain derived neurotrophic factor (BDNF) genetic polymorphism (Val66Met) in suicide: A study of 512 cases

2008; Wiley; Volume: 150B; Issue: 4 Linguagem: Inglês

10.1002/ajmg.b.30849

1552-485X

Federica Zarrilli, Antonella Angiolillo, Giuseppe Castaldo, Lorenzo Chiariotti, S Keller, Silvana Sacchetti, Ana Marušić, Tina Žagar, Vladimir Carli, A. Roy, Marco Sarchiapone,

Autism Spectrum Disorder Research

American Journal of Medical Genetics Part B: Neuropsychiatric GeneticsVolume 150B, Issue 4 p. 599-600 Letter to the Editor Brain derived neurotrophic factor (BDNF) genetic polymorphism (Val66Met) in suicide: A study of 512 cases† F. Zarrilli, F. Zarrilli Facoltà di Scienze MFN, Università del Molise, Isernia, ItalySearch for more papers by this authorA. Angiolillo, A. Angiolillo Facoltà di Scienze MFN, Università del Molise, Isernia, ItalySearch for more papers by this authorG. Castaldo, G. Castaldo Dipartimento di Biochimica e Biotecnologie Mediche and Facoltà di Scienze Biotecnologiche, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorL. Chiariotti, L. Chiariotti Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorS. Keller, S. Keller Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorS. Sacchetti, S. Sacchetti Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorA. Marusic, A. Marusic University of Primorska, Primorska, SloveniaSearch for more papers by this authorT. Zagar, T. Zagar University of Primorska, Primorska, SloveniaSearch for more papers by this authorV. Carli, V. Carli Department of Health Sciences, University of Molise, Campobasso, ItalySearch for more papers by this authorA. Roy, A. Roy Psychiatry Service, Department of Veteran Affairs, Newark, New JerseySearch for more papers by this authorM. Sarchiapone, Corresponding Author M. Sarchiapone [email protected] Department of Health Sciences, University of Molise, Campobasso, ItalyVia De Sanctis, Campobasso 86100, Italy.Search for more papers by this author F. Zarrilli, F. Zarrilli Facoltà di Scienze MFN, Università del Molise, Isernia, ItalySearch for more papers by this authorA. Angiolillo, A. Angiolillo Facoltà di Scienze MFN, Università del Molise, Isernia, ItalySearch for more papers by this authorG. Castaldo, G. Castaldo Dipartimento di Biochimica e Biotecnologie Mediche and Facoltà di Scienze Biotecnologiche, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorL. Chiariotti, L. Chiariotti Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorS. Keller, S. Keller Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorS. Sacchetti, S. Sacchetti Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università “Federico II”, CEINGE-Biotecnologie Avanzate, Naples, ItalySearch for more papers by this authorA. Marusic, A. Marusic University of Primorska, Primorska, SloveniaSearch for more papers by this authorT. Zagar, T. Zagar University of Primorska, Primorska, SloveniaSearch for more papers by this authorV. Carli, V. Carli Department of Health Sciences, University of Molise, Campobasso, ItalySearch for more papers by this authorA. Roy, A. Roy Psychiatry Service, Department of Veteran Affairs, Newark, New JerseySearch for more papers by this authorM. Sarchiapone, Corresponding Author M. Sarchiapone [email protected] Department of Health Sciences, University of Molise, Campobasso, ItalyVia De Sanctis, Campobasso 86100, Italy.Search for more papers by this author First published: 29 August 2008 https://doi.org/10.1002/ajmg.b.30849Citations: 37 † Please cite this article as follows: Zarrilli F, Angiolillo A, Castaldo G, Chiariotti L, Keller S, Sacchetti S, Marusic A, Zagar T, Carli V, Roy A, Sarchiapone M. 2008. Brain Derived Neurotrophic Factor (BDNF) Genetic Polymorphism (Val66Met) in Suicide: A Study of 512 Cases. Am J Med Genet Part B 150B:599–600. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES Berton O, McClung CA, Dileone RJ, Krinshan V, Renthal W, Russo SJ. 2006. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311: 864–868. Dwivedi Y, Mondal AC, Rizavi HS, Conley RR. 2005. Suicide brain is associated with decreased expression of neurotrophins. Biol Psychiatry 58: 315–324. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. 2003. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60: 804–815. Hashimoto K. 2007. BDNF variant linked to anxiety-related behaviors. Bioessays 29(2): 116–119. Hashimoto T, Lewis DA. 2006. BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia. Am J Psychiatry 163: 534–537. Itoh K, Hashimoto K, Kumakiri C, Shimizu E, Iyo M. 2004. Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects. Am J Med Genet Part B 124B: 61–63. Naoe Y, Shinkai T, Hori H, Fukunata Y, Utsonomiy A, Sakata S. 2007. No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis. Neurosci Lett 415: 108–112. Rybakowski JK, Borkowska A, Czerski PM, Dnitrzak-Weglarz M, Hauser J. 2003. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 5: 468–472. Rybakowski JK, Borkowska A, Skibinska M, Szczepankiewicz A, Kapelski P, Leszczynska-Rodziewicz A, et al. 2006. Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Mol Psychiatry 11: 122–124. Sarchiapone M, Roy A, Carli V, et al. 2008. Association of polymorphism (Val66Met) of brain-derived neurotrophic factor (BDNF) with attempting suicide in depressed patients. Neuropsychobiology 57(3): 139–145. Citing Literature Volume150B, Issue45 June 2009Pages 599-600 ReferencesRelatedInformation