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Analgesic and anti-inflammatory dose–response relationship of 7.5 and 15mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study

2006; Elsevier BV; Volume: 36; Issue: 1 Linguagem: Inglês

10.1016/j.ijom.2006.09.006

1399-0020

Adriana Maria Calvo, Vivien Thiemy Sakai, Fernando Paganeli Machado Giglio, K.C.S. Modena, Bella Luna Colombini Ishikiriama, V. Benetello, Fabiano Sakamoto, Thiago Machado Freire, Thiago José Dionísio, José Roberto Pereira Lauris, Alceu Sérgio Trindade, Flávio Augusto Cardoso de Faria, Carlos Ferreira Santos,

Dental Radiography and Imaging

Fifty patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Meloxicam 7.5 or 15 mg was once daily administered in a double-blind, randomized and crossover manner after the surgery for 4 days. Objective and subjective parameters were recorded for comparison of postoperative courses. Patients treated with 7.5 mg meloxicam who underwent osteotomy reported higher pain scores at 1.5, 3, 4, 10, 12 and 16 h (P < 0.05) and ingested a greater amount of rescue analgesic medication (P < 0.05) than those who did not require osteotomy. A higher percentage of patients who underwent osteotomy medicated with 7.5 mg meloxicam needed rescue medication as compared to those who did not require osteotomy (P < 0.05). There was a similar mouth opening at suture removal compared with preoperative values for both doses (P > 0.05). There were no significant differences concerning swelling observed on the 2nd or 7th postoperative days in comparison with baseline (P > 0.05) between the two doses. Pain, trismus and swelling after lower third molar removal not requiring osteotomy can be successfully controlled by a dose regimen of 7.5 mg meloxicam once daily. For more aggressive extractions 15 mg meloxicam is advisable.