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Tau aggregation into fibrillar polymers: taupathies

2000; Wiley; Volume: 476; Issue: 1-2 Linguagem: Inglês

10.1016/s0014-5793(00)01676-8

1873-3468

Jesús Ávila,

Neurological diseases and metabolism

Different neurological disorders, known as taupathies have been recently described. In these disorders it has been suggested that modifications in the microtubule‐associated protein tau could cause neural degeneration in specific regions. Although these regions are different in the different taupathies, some common features appear to occur in all of them: abnormal hyperphosphorylation of tau and aberrant tau aggregation. These two features are commented upon in this review.