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Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality

2013; Elsevier BV; Volume: 122; Issue: 22 Linguagem: Inglês

10.1182/blood-2013-05-501510

1528-0020

Joseph Pidala, Tao Wang, Michael Haagenson, Stephen R. Spellman, Medhat Askar, Minoo Battiwalla, Lee Ann Baxter‐Lowe, Menachem Bitan, Marcelo Fernández-Viña, Manish J. Gandhi, Ann A. Jakubowski, Martin Maiers, Susana R. Marino, Steven G. E. Marsh, Machteld Oudshoorn, Jeanne Palmer, Vinod K. Prasad, Vijay Reddy, Olle Ringdén, Wael Saber, Stella Santarone, Kirk R. Schultz, Michelle Setterholm, Elizabeth Trachtenberg, E. Victoria Turner, Ann E. Woolfrey, Stephanie J. Lee, Claudio Anasetti,

T-cell and B-cell Immunology

Key Points Amino acid substitution at peptide-binding residues of the HLA class I molecule is associated with graft-versus-host disease and mortality. Avoidance of donor-recipient combinations that result in amino acid substitution at peptide-binding residues may improve transplant outcomes.