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Revisão Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Vitiligo - Part 2 - classification, histopathology and treatment

2014; Elsevier BV; Volume: 89; Issue: 5 Linguagem: Inglês

10.1590/abd1806-4841.20142717

ISSN

1806-4841

Autores

Adriane Reichert Faria, Roberto Gomes Tarlé, Gerson Dellatorre, Marcelo Távora Mira, Caio César Silva de Castro,

Tópico(s)

Skin Protection and Aging

Resumo

In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes. Physical and pharmacological treatment strategies aim to control the autoimmune damage and stimulate melanocyte migration from the unaffected edges of lesions and the outer hair follicle root sheath to the affected skin; moreover, surgical treatments can be combined with topical and physical treatments.

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