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BIBTEX RIS

Schistosoma mansoni: structural damage after treatment with oxamniquine

1987; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 82; Issue: suppl 4 Linguagem: Inglês

10.1590/s0074-02761987000800067

1678-8060

Ageu Magalhães Filho, Maria Eliane Bezerra de Mélo, P Padovan, Isaíras Pereira Padovan,

Research on Leishmaniasis Studies

The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.