Coumarins and Carbazoles with Antiplasmodial Activity from Clausena harmandiana
2000; Thieme Medical Publishers (Germany); Volume: 66; Issue: 03 Linguagem: Inglês
10.1055/s-2000-8558
ISSN1439-0221
AutoresChavi Yenjai, Somkrit Sripontan, Prachack Sriprajun, Prasat Kittakoop, Amnuay Jintasirikul, Morakot Tanticharoen, Yodhathai Thebtaranonth,
Tópico(s)Traditional and Medicinal Uses of Annonaceae
ResumoActivity guided fractionation of extracts from Clausena harmandiana have led to the identification of four known compounds, heptaphylline (1), clausine K (2), dentatin (5), and clausarin (6). All these compounds, except clausine K (2), exhibited antiplasmodial activity against Plasmodium falciparum. While the new dimethylated derivative 4, derived from 2, showed no antiplasmodial activity, the monomethylated product 3 (clausine H) exhibited activity comparable to that observed for compounds 1 and 5.
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