SURAMIN FOR TREATMENT OF ADRENOCORTICAL CARCINOMA
1989; Elsevier BV; Volume: 334; Issue: 8657 Linguagem: Inglês
10.1016/s0140-6736(89)90462-5
ISSN1474-547X
Autores Tópico(s)Neuroendocrine Tumor Research Advances
Resumorespond to metoclopramide, domperidone, ranitidine, amantadine, levodopa, carbamazepine, clonidine, prazosin, haloperidol, methysergide, or metoprolol.He improved slightly with the application of scopolamine patches, which had to be stopped because of side-effects.Intramuscular chlorpromazine (25 mg) would sometimes prevent attacks for up to a week.He was prescribed baclofen 10 mg, three times daily, after which his hiccups ceased for five days.When they recurred, baclofen dose was increased to 20 mg three times daily which has been successful, with only an occasional solitary hiccup.When he ran out of tablets for two days, the hiccups returned with their former ferocity.He has now remained under control on this medication for three months, has gained weight, and is feeling well for the first time in 30 years.The family history suggests transmission by an autosomal dominant gene.
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