Therapy of localized and regional lymphosarcoma of childhood
1971; Wiley; Volume: 27; Issue: 6 Linguagem: Inglês
10.1002/1097-0142(197106)27
ISSN1097-0142
AutoresRhomes J. A. Aur, H. Omar Hustu, Joseph V. Simone, Charles B. Pratt, Donald Pinkel,
Tópico(s)Sarcoma Diagnosis and Treatment
ResumoLocalized and regional lymphosarcoma in children has a limited prognosis when treated with conventional therapy. Recurrences and conversion to acute leukemia occur in a significant proportion of patients. In this study, intensive combination chemotherapy and radiotherapy were given to 8 children with localized or regional lymphosarcoma. Initially, they received prednisone and vincristine along with cobalt60 radiotherapy to physically detectable tumor sites. This was followed by daily administration of 6-mercaptopurine, weekly methotrexate and cyclophosphamide, and 15-day courses of prednisone and vincristine every 10 weeks. Six children attained remission and are currently well for 16-27 months. One child died in complete remission of viral pneumonia after 5 months of continuation therapy. Another child showed only a partial and temporary response. We conclude that intensive chemotherapy combined with local radiotherapy results in long disease-free remissions and prevents or delays development of leukemia.
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