Sialyltransferase: A novel acute-phase reactant
1993; Elsevier BV; Volume: 105; Issue: 1 Linguagem: Inglês
10.1016/0305-0491(93)90165-2
ISSN0305-0491
AutoresJ.C. Jamieson, Gwen McCaffrey, Phyllis Gwen Harder,
Tópico(s)Galectins and Cancer Biology
Resumo1. Proteins that are released into the circulation in elevated amounts in injured mammals are referred to as acute-phase reactants. Most are liver synthesized glycoproteins of the secretable type. However, Gal-β(1→4)-GlcNAc-α(2→6)-sialyltransferase (EC 2.4.99.1) is a novel acute-phase reactant since it is a Golgi membrane-bound enzyme rather than a secretable glycoprotein. 2. The role of glucocorticoids and cytokines in the control of synthesis and expression of acute-phase glycoproteins, including sialyltransferase, is discussed. 3. The acute-phase behaviour of Gal-β(1→4)-GlcNAc-α(2→6)-sialyltransferase is dependent on the release of the enzyme from the Golgi in the acute-phase state. The mechanism of release of a catalytically active form of the enzyme is described.
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