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Development of an acute polyarthritis in rats treated with prolactin

1959; Wiley; Volume: 2; Issue: 5 Linguagem: Inglês

10.1002/1529-0131(195910)2

1529-0131

G. Jasmin, P Bois,

Hormonal and reproductive studies

Hypophysectomized and adrenalectomized desoxycorticosterone-maintained rats were treated with prolactin during a period of 15 days. Acute polyarthritis developed between the 10th and 12th days in most adrenalectomized rats, whereas no such lesions could be evidenced in hypophysectomized animals. Prolactin, on the other hand, had no influence on the course of a croton-oil induced inflammation. The possible significance of these observations is discussed. Rattos mantenite, post hypophysectomia e adrenalectomia, per disoxycorticosterona esseva tractate con prolactina durante un periodo de 15 dies. Polyarthritis acute se disveloppava inter le decime e le dece-secunde die in le majoritate del adrenalectomisate rattos, durante quenulle tal lesiones esseva manifeste in hypophysectomisate animales. Prolactina, del altere latere, habeva nulle influentia super le curso de un inflammation inducite per oleo de coton. Le signification possibile de iste observationes es discutite.