Produção Nacional
Revisado por pares
Efeitos do betacaroteno e do tabagismo sobre a remodelação cardíaca pós-infarto do miocárdio
2007; Sociedade Brasileira de Cardiologia (SBC); Volume: 89; Issue: 3 Linguagem: Inglês
10.1590/s0066-782x2007001500002
ISSN1678-4170
AutoresLeonardo A. M. Zornoff, Daniella R. Duarte, Marcos Ferreira Minicucci, Paula S. Azevedo, Beatriz B. Matsubara, Luiz Shiguero Matsubara, Álvaro Oscar Campana, Sérgio Alberto Rupp de Paiva,
Tópico(s)Cardiovascular Function and Risk Factors
ResumoTo analyze the effects of beta-carotene on the ventricular remodeling process following myocardial infarction (MI) in rats exposed to cigarette smoke.After acute myocardial infarction (AMI), the animals were divided into four groups: 1) Group C, 24 animals that were given standard diet; 2) Group BC, 26 animals that were given beta-carotene; 3) Group ECS, 26 animals that were given standard diet and were exposed to cigarette smoke; and 4) Group BC+ECS, 20 animals that were given beta-carotene and were exposed to cigarette smoke. After six months, a morphofunctional study was performed. We used a 5% significance level.As regards diastolic areas (DA) and systolic areas (SA), the values for the BC group were higher than those for the C group. If DA/body weight (BW) and SA/BW are considered, the values for group BC+ECS were higher than the values for group C. As regards the fractional area change, we observed significant differences between ECS (lower values) and C (higher values) and between BC (lower values) and C (higher values). Differences between groups regarding infarction size were not observed. The ECS group presented higher values for myocyte cross-section area (MCA) than control animals. Additionally, the BC+ECS group presented higher MCA values than the BC, ECS and C groups.After myocardial infarction, smoking and beta-carotene intensified the heart remodeling process; harmful effects of the remodeling process were heightened when the two treatments were used in conjunction.
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