The immediate cardiovascular effects of Althesin (Glaxo CT 1341), a steroid induction agent, and thiopentone in man
1972; Wiley; Volume: 27; Issue: 4 Linguagem: Inglês
10.1111/j.1365-2044.1972.tb08241.x
ISSN1365-2044
AutoresA.J. COLEMAN, J. W. Downing, W P Leary, D G Moyes, M. Styles,
Tópico(s)Medical History and Innovations
ResumoAnaesthesiaVolume 27, Issue 4 p. 373-378 Free Access The immediate cardiovascular effects of Althesin (Glaxo CT 1341), a steroid induction agent, and thiopentone in man A. J. Coleman, A. J. Coleman A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorJ. W. Downing, J. W. Downing A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorW. P. Leary, W. P. Leary A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorD. G. Moyes, D. G. Moyes A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorM. Styles, M. Styles A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this author A. J. Coleman, A. J. Coleman A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorJ. W. Downing, J. W. Downing A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorW. P. Leary, W. P. Leary A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorD. G. Moyes, D. G. Moyes A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this authorM. Styles, M. Styles A. J. Coleman, MB, BS, FFARCS, Professor of Anaesthetics, J. W. Downing, MB, BCh(Rand), FFA(SA), FFARCS, Principal Anaesthetist Senior Lecturer; W. P. Leary, MSc, MB, BCh(Rand), DPhil(Oxori), FCP(SA), MRCP, Clinical Pharmacologist; D. G. Moyes, MRCS, LRCP, MB, ChBiBirrri), FFARCS, Principal Anaesthetist)Senior Lecturer, M. Styles, MB, BS, MRCS, LRCP, FFARCS, Senior Anaesthetist, Faculty of Medicine, University of Natal, Durban. Address for reprints: Professor A. J. Coleman, Department of Anaesthetics, Faculty of Medicine, University of Natal, P.O. Box 39, Congella, Durban, South Africa.Search for more papers by this author First published: October 1972 https://doi.org/10.1111/j.1365-2044.1972.tb08241.xCitations: 16AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Child, KJ., Currie, J.P., Davis, B., Dodds, M.G., Pearce, D.R. & Twissell, DJ. (1971). The pharmacological properties in animals of CT1341-a new steroid anaesthetic agent. British Journal of Anaesthesia, 43, 2. 2 Campbell, D., Forrester, A.C, Miller, D.C, Hutton, L, Kennedy, J.A., Lawrie, T.D.V., Lorimer, A.R. & McCall, D. (1971). A preliminary clinical study of CT1341-a steroid anaesthetic agent. British Journal of Anaesthesia, 43, 14. 3 Savege, T.M., Foley, E.I., Coultas, R.J., Walton, B., Strunin, L., Simpson, B.R. & Scott, D.F. (1971). CT1341 some effects in man. Anaesthesia, 26, 402. 4 Clarke, R.S.J., Montgomery, S.J., Dundee, J.W. & Bovill, J.G. (1971). Clinical studies of induction agents. XXXIX: CT1341, a new steroid anaesthetic. British Journal of Anaesthesia, 43, 947. 5 Clarke, R.S., J. Glaxo symposium of steroid anaesthesia. Stoke, January, 1972. 6 Williams, J.C.P., O'Donovan, T.P.B. Wood, E.H. (1966). A method for the calculation of areas under indicator-dilution curves. Journal of Applied Physiology, 21, 695. 7 Aperia, A. (1940). Total peripheral resistance formula. Skandinavisches Archly fur Physiologie, Supplement 16, 1. 8 Dobkin, A.B. & Wyant, G.M. (1957). The physiological effects of intravenous anaesthesia on man. Canadian Anaesthetists Society Journal, 4, 295. 9 Etsten, B. & Li, T.H. (1955). Haemodynamic changes during thiopental anesthesia in humans. Journal of Clinical Investigation, 34, 500. 10 FieIdman, E.J., Ridley, R.W. & Wood, E.H. (1955). Haeomodynamic studies during thiopental sodium and nitrous oxide anesthesia in humans. Anesthesiology, 16, 473. 11 Flickinger, H., Fraimow, W., Cathcart, R.T. & Nealon, T.F. (1961). Effect of thiopental induction on cardiac output in man. Current Researches in Anesthesia and Analgesia, 40, 693. Citing Literature Volume27, Issue4October 1972Pages 373-378 ReferencesRelatedInformation
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