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Complete mole in a dichorionic twin pregnancy after intracytoplasmic sperm injection

2013; Thieme Medical Publishers (Germany); Volume: 35; Issue: 1 Linguagem: Inglês

10.1590/s0100-72032013000100008

1806-9339

Tiago José Santos de Matos Ferraz, Carla Bartosch, Carla Ramalho, Filipa Carvalho, Berta Cecília Campos Lima de Carvalho, Otília Brandão, Nuno Montenegro,

Prenatal Screening and Diagnostics

A dichorionic twin pregnancy with complete hydatidiform mole and coexistent fetus is a rare and challenging situation, whose pathogenesis has not been yet fully understood. We present a case of a 39-year-old woman who underwent intracytoplasmic sperm injection with two embryos transfer. The 12-week gestation ultrasound examination revealed normal fetus and placenta with features of hydatidiform mole, leading to pregnancy termination. Autopsy and histological examinations diagnosed a complete mole coexisting with a normal fetus, and the genetic analysis showed a diploid fetus with biparental genome and molar tissue with paternal diploidy. This case highlighted that complete molar pregnancies may still occur even though pregnancy is achieved after intracytoplasmic sperm injection. A review of the literature was performed by collecting data from the few similar reported cases and by commenting on the pathogenesis of this rare condition.