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The biosynthesis of fungal metabolites. Part VII. Production and biosynthesis of 4,7-dimethoxy-5-methylcoumarin in Aspergillus variecolor

1975; Issue: 6 Linguagem: Inglês

10.1039/p19750000554

2050-8255

Kuldip K. Chexal, Christopher Fouweather, J. S. E. Holker,

Cancer Treatment and Pharmacology

4,7-Dimethoxy-5-methylcoumarin (I)(4,7-dimethoxy-5-methylchromen-2-one) is shown to be a metabolite of Aspergillus variecolor, strain IMI 53749. Incorporation of [2-14C]acetate into this natural product shows that it is derived on the β-ketide pathway. A synthesis of compound (I) is reported.