Molecular epidemiology of parvoviruses
1995; Academic Press; Volume: 6; Issue: 6 Linguagem: Inglês
10.1016/s1044-5773(05)80018-6
ISSN1098-1292
Autores Tópico(s)Animal Virus Infections Studies
ResumoMolecular epidemiological studies of paruoviruses are complicated by the low levels of variation in the DNA genome of the viruses. Nevertheless, use of restriction enzyme analysis, DNA sequencing and monoclonal antibody analysis of epitope variation has been used to examine the distribution of virus strains in nature. Comparison of canine parvovirus and the related viruses from other carnivores showed that a number of variant strains of the viruses could be identfied by DNA sequence and antigenic analysis. Among CPV isolates some strains replaced previous antigenic types, while other variant antigenic types coexisted in nature. The viruses are apparently able to spread world wide, as most geographically separated viruses are not genetically distinct. The human B19 parvovirus has been examined by restriction enzyme analysis and limited DNA sequencing, and a variety of characteristic strains identified. Some were found world wide, while others were apparently found to be associated with certain countries.
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