Differential regulation of γ-crystallin genes during mouse lens development
1987; Elsevier BV; Volume: 119; Issue: 1 Linguagem: Inglês
10.1016/0012-1606(87)90227-2
ISSN1095-564X
AutoresM. Murer‐Orlando, Roger C. Paterson, Si Lok, Lap‐Chee Tsui, Martin L. Breitman,
Tópico(s)Molecular Biology Techniques and Applications
ResumoUsing gene-specific probes derived from four mouse gamma-crystallin cDNAs, we have examined the regulation of different members of the mouse gamma-crystallin gene family during lens development. Our analysis revealed that, while the different gamma-crystallin genes appear to be coordinately activated during embryogenesis, the steady-state levels of their corresponding transcripts are differentially regulated, resulting in variations in the relative abundance of individual species at different stages of development. This complex pattern of gene regulation presumably accounts for one of the mechanisms determining the spatial distribution of different gamma-crystallins within the lens.
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