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Short-term immunosuppressive therapy does not affect the density of the pre-existing bone around titanium implants placed in rabbits

2003; UNIVERSIDADE DE SÃO PAULO; Volume: 17; Issue: 4 Linguagem: Inglês

10.1590/s1517-74912003000400012

1678-8079

Poliana Mendes Duarte, Getúlio da Rocha Nogueira Filho, Enílson Antônio Sallum, Antônio Wilson Sallum, Francisco Humberto Nociti,

Orthopaedic implants and arthroplasty

The aim of this study was to evaluate the influence of the administration and withdrawal of cyclosporin A/nifedipine on the bone density in a lateral area adjacent to implants placed in rabbits. Two screw-type titanium implants were placed bilaterally in twenty-eight New Zealand rabbits. The animals were assigned to one of the following groups and received daily subcutaneous injections for 14 days: Groups A and C: vehicle (dimethyl sulfoxide); Groups B and D: CsA (10 mg/kg) plus nifedipine (50 mg/kg). The animals in Groups A and B were sacrificed 14 days postoperatively and, in Groups C and D, 42 days postoperatively. After sacrifice, the tibiae were removed and undecalcified sections were obtained. Bone density was obtained in a 500 mm-wide zone lateral to the implant surface. Intergroup analysis showed no significant difference (p > 0.05) in the degree of bone density between control and test groups either on day 14 or on day 42. Thus, it appears that a short-term immunosuppressive therapy may not present a negative influence on the density of the pre-existing bone around titanium implants placed in rabbits.