Axinelloside A, an Unprecedented Highly Sulfated Lipopolysaccharide Inhibiting Telomerase, from the Marine Sponge, Axinella infundibula 1
2005; American Chemical Society; Volume: 127; Issue: 38 Linguagem: Inglês
10.1021/ja052688r
ISSN1943-2984
AutoresKaoru Warabi, Toshiyuki Hamada, Yoichi Nakao, Shigeki Matsunaga, Hiroshi Hirota, Rob W. M. van Soest, Nobuhiro Fusetani,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoAxinelloside A was isolated from the lipophilic extract of the Japanese marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC(50) 2.0 microg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.
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