Phospholipase D and cell signaling
1993; Elsevier BV; Volume: 5; Issue: 1 Linguagem: Inglês
10.1016/0952-7915(93)90090-f
ISSN1879-0372
Autores Tópico(s)Receptor Mechanisms and Signaling
ResumoPhospholipase D, which hydrolyzes phospholipids (primarily hosphatidylcholine) to generate phosphatidic acid, has emerged as a critical component in cellular signal transduction. Research during the past year has confirmed and extended the view that phosphatidic acid and its dephosphorylated product, sn-1,2-diacylglycerol, are important intracellular second messengers and that the coupling of phospholipase D to specific receptors occurs through multiple mechanisms involving protein kinase C, protein tyrosine kinase, Ca2+ and GTP-binding proteins.
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