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RELATIONS OF EFFECTIVE RENAL BLOOD FLOW AND GLOMERULAR FILTRATION TO TUBULAR EXCRETORY MASS IN NORMAL MAN 1

1940; American Society for Clinical Investigation; Volume: 19; Issue: 5 Linguagem: Inglês

10.1172/jci101179

1558-8238

William Goldring, Herbert Chasis, Hilmert A. Ranges, Homer W. Smith,

Renal Diseases and Glomerulopathies

In 1938 Smith, Goldring and Chasis (12) de- scribed methods for measuring the "effective renal blood flow" (diodrast clearance) and the " tubular excretory mass " (diodrast Tm) by the excretion of diodrast at low and high plasma lev- els.The present report concerns the application of these methods to normal subjects under stand- ard or quasi-basal conditions, with special refer- ence to the quantitative relations between the dio- drast clearance, the inulin clearance and diodrast Tm in various subjects.The subjects examined here were convalescent, volunteer patients of the Third (New York Uni- versity) Medical Division of Bellevue Hospital, and were selected as carefully as possible to ex- clude renal disease.Clearance determinations were carried out in the morning without break- fast, although in a few instances a glass of orange juice was allowed.The subject was hydrated by the administration of one liter of water the night before; the water was measured out for him and he was allowed to take it ad libitum and without supervision.The next morning a second liter of water was taken between 7:00 and 8:30 a.m., and the subject was allowed out of bed momentarily.At about 9:00 a.m. an intravenous infusion con- taining the requisite concentrations of diodrast, 1 This investigation has been aided in part by a grant from the Commonwealth Fund.The authors are indebted to the Winthrop Chemical Company for generously supplying some of the diodrast used in the later observations, and to Messrs. Hynson, Westcott and Dunning for the preparation of phenol red in sterile 10 per cent solution.They also wish to ex- press their appreciation of the continued