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Anticholinergic Treatment of Watery Rhinorrhea

1990; SAGE Publishing; Volume: 4; Issue: 1 Linguagem: Inglês

10.2500/105065890782020999

1539-6290

Niels Mygind, P Borum,

Sinusitis and nasal conditions

When the anticholinergic drug ipratropium bromide is given as a nasal spray, it can reach the glandular cholinoceptors and block the secretory response to methacholine. Nine placebo-controlled clinical trials have shown that the treatment significantly reduces watery rhinorrhea in patients with perennial rhinitis not responsive to other types of treatment. To avoid a sensation of nasal dryness as a side effect from spraying, it is important in the individual patient to match the dosage to the severity of hypersecretion. Ipratropium has no effect on sneezing or on nasal blockage.