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Synthesis and characterization of potential tumor scintigraphic agents

1987; Pergamon Press; Volume: 38; Issue: 8 Linguagem: Inglês

10.1016/0883-2889(87)90138-9

1878-1128

Almah Bt. Awaluddin, Jacqueline J.L. Jacobs, David W. A. Bourne, Desmond J. Maddalena, J.G. Wilson, Rex E. Boyd,

Lanthanide and Transition Metal Complexes

Potential tumor imaging radiopharmaceutical agents have been prepared by attaching a cisplatin derivative to a ligand capable of forming a stable complex with 99mTc. Three new organometallic compounds, with iminodiacetic acid as the 99mTc chelating group and 2,3-diaminopropionamide as the platinum complexing group, have been prepared and characterized. Preliminary biodistribution studies in tumor bearing mice support the utility of this approach.