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Over-the-Counter Daytime Sedatives

1973; American Medical Association; Volume: 223; Issue: 1 Linguagem: Inglês

10.1001/jama.1973.03220010017003

1538-3598

Karl Rickels,

Olfactory and Sensory Function Studies

A two-week double-blind clinical trial, conducted with 166 general-practice patients displaying mild to moderate symptoms of anxiety and tension, compared the relative safety and efficacy of Compoz, the largest-selling over-the-counter daytime sedative; aspirin, used by many for tension relief; chlordiazepoxide; and placebo. More side effects were reported with Compoz and chlordiazepoxide than with either aspirin or placebo. Neither Compoz nor aspirin could be differentiated from placebo, while chlordiazepoxide produced significantly more symptomatic relief than Compoz, aspirin, or placebo. Further studies of daytime sedatives are considered necessary to protect the public from medications of questionable safety and efficacy.