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Cancer biology, analgesics, and anaesthetics: is there a link?

2012; Elsevier BV; Volume: 109; Issue: 2 Linguagem: Inglês

10.1093/bja/aes255

1471-6771

Lesley Colvin, Marie Fallon, Donal J. Buggy,

Pediatric Pain Management Techniques

The incidence of cancer continues to increase, despite considerable investment in prevention.1 Additionally, with improved oncological treatments, more people are living with, or being cured of, cancer, and many of these will have disease or treatment-related chronic pain, requiring analgesia.2 3 Currently, there is much interest in how analgesics and anaesthetics may impact on cancer biology (especially cancer recurrence and metastases) and consequently on survival.4 There are at least two areas of particular interest: first, how regional techniques or specific general anaesthetics used for cancer surgery may impact long-term survival, and secondly, how both endogenous and exogenous opioids may modulate cancer biology.