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The Participation of Bone in the Sodium and Potassium Metabolism of the Rat. II The effect of variation of electrolyte intake, acidosis and alkalosis

1963; Wiley; Volume: 57; Issue: 4 Linguagem: Inglês

10.1111/j.1748-1716.1963.tb02600.x

1365-201X

N. Norman,

Renal function and acid-base balance

Abstract Rats were examined according to a previously described technique N orman 1963) permitting the simultaneous measurement of total exchangeable sodium and potassium in their body as well as the total and exchangeable concentration of sodium and potassium in their skeleton. The effect of various combinations of sodium depletion, potassium depletion, sodium loading, acidosis and alkalosis was studied. Simple sodium depletion caused a loss of 10 per cent of body sodium, 90 per cent of the loss was accounted for by shrinkage of the extracellular fluid volume. When acidosis was induced in addition, sodium was given off from the exchangeable bone sodium fraction. Potassium depletion caused a picture similar to that of starvation. The potassium depleted rats had a greatly reduced ability to handle a metabolic alkalosis. The participation of bone sodium and potassium in the metabolism of the rats was smaller than found by others. The mean difference from maximum storage of sodium in alkalosis, to maximum depletion in acidosis, corresponded to 10 per cent of the total bone sodium concentration. Bone potassium concentration showed great constancy, with no parallel to the variations in bone sodium.