Inhibition of host cellular ribonucleic acid synthesis by glycoprotein of mumps virus
1984; Elsevier BV; Volume: 135; Issue: 2 Linguagem: Inglês
10.1016/0042-6822(84)90187-9
ISSN1096-0341
AutoresAkio Yamada, Masato Tsurudome, Michiko Hishiyama, Yasuhiko Ito,
Tópico(s)vaccines and immunoinformatics approaches
ResumoAfter infection with mumps virus, cellular ribonucleic acid synthesis of a murine lymphoma cell line, EL4, was appreciably depressed. The inactivation of viral infectivity by ultraviolet irradiation or the treatment of cells with mouse interferon did not abolish the inhibiting effect, suggesting that virus replication is not required for the depressed RNA synthesis. Envelope glycoproteins isolated from disrupted mumps virus caused inhibition of cellular RNA synthesis. The addition of low concentrations of specific antibody enhanced the inhibitory effect, probably through the formation of aggregates of glyco-proteins. On the contrary, the glycoproteins showed no effect on RNA synthesis in the presence of cytochalasin D.
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