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Monosodium Glutamate Administration to the Newborn Reduces Reproductive Ability in Female and Male Mice

1977; American Association for the Advancement of Science; Volume: 196; Issue: 4288 Linguagem: Inglês

10.1126/science.557837

1095-9203

William J. Pizzi, June E. Barnhart, Don J. Fanslow,

Regulation of Appetite and Obesity

Monosodium glutamate (MSG) administered during the neonatal period (days 2 to 11) resulted in a sequence of events that were manifested in adulthood. Reproductive dysfunction was seen in both female and male animals. Females treated with MSG had fewer pregnancies and smaller litters, while males treated with MSG showed reduced fertility. The MSG-treated mice showed increased body weight and decreased pituitary, thyroid, ovary, or testis weights.