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Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus

2011; Elsevier BV; Volume: 53; Issue: 8 Linguagem: Inglês

10.1016/j.tetlet.2011.12.021

1873-3581

Eunice Molinar, Nivia Ríos, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla‐Rios,

Marine Sponges and Natural Products

Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A–C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.