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Taiwankadsurins A, B, and C, Three New C19 Homolignans from Kadsura philippinensis

2005; American Chemical Society; Volume: 7; Issue: 23 Linguagem: Inglês

10.1021/ol052227a

1523-7060

Ya‐Ching Shen, Yu‐Chi Lin, Yuan‐Bin Cheng, Yao‐Haur Kuo, Chia‐Ching Liaw,

Magnolia and Illicium research

Three novel C19 homolignans, designated taiwankadsurins A (1), B (2), and C (3), were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of 1−3, which have a 3,4-{1'-[(Z)-2' '-methoxy-2' '-oxo-ethylidene]}-pentano(2,3-dihydro-benzo[b]furano)-3-(2' ''-methoxycarbonyl-2' ''-hydroxy-2' '',3'-epoxide) skeleton, were determined by spectroscopic analyses, especially 2D NMR techniques (HMBC and NOESY). Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells.