And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis
2002; Elsevier BV; Volume: 84; Issue: 2-3 Linguagem: Inglês
10.1016/s0300-9084(02)01379-2
ISSN1638-6183
AutoresNigel J. Waterhouse, Jean‐Ehrland Ricci, Douglas R. Green,
Tópico(s)interferon and immune responses
ResumoIdentification of pro-apoptotic activities for a variety of proteins normally resident in the mitochondrial inter-membrane space has substantiated the role of mitochondria as integral to the apoptotic process. Cytochrome c is involved in apoptosome formation and caspase activation, SMAC/Diablo deregulates the inhibitor of apoptosis proteins, apoptosis-inducing factor may play a role in chromatin condensation and release of other proteins such as adenylate kinase may adversely affect cellular metabolism and contribute to the death of a cell if the downstream apoptotic pathway is blocked. It is still unclear how these proteins are released from the mitochondria. Recent advances in our knowledge of mitochondrial outer-membrane permeabilization and the consequences of this event on mitochondria will be discussed.
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