Cytotoxic effects of butyrate and other ‘differentiation inducers’ on immature lymphoid cells
1982; Elsevier BV; Volume: 104; Issue: 4 Linguagem: Inglês
10.1016/0006-291x(82)91378-x
ISSN1090-2104
Autores Tópico(s)Click Chemistry and Applications
ResumoA connection between the processes of cell death and differentiation is suggested by observations which show that chemical inducers of differentiation are cytotoxic to CCRF-CEM human leukaemic lymphoblasts, cells which have properties typical of immature lymphoid cells. Sodium n-butyrate, salts of other short-chain fatty acids, 5-azacytidine, hypoxanthine, L-ethionine and dimethyl sulphoxide were all cytotoxic to these cells at concentrations similar to those reported to produce reversible growth inhibition in more mature lymphocytes or growth inhibition and differentiation in other cell types. Only actively cycling cells were susceptible to killing by n-butyrate. Inhibitory effects of these compounds on DNA methylation are postulated to be responsible for their cytotoxic actions.
Referência(s)